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Overexpression of SIRT1 in Mouse Forebrain Impairs Lipid/Glucose Metabolism and Motor Function

SIRT1 plays crucial roles in glucose and lipid metabolism, and has various functions in different tissues including brain. The brain-specific SIRT1 knockout mice display defects in somatotropic signaling, memory and synaptic plasticity. And the female mice without SIRT1 in POMC neuron are more sensi...

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Detalles Bibliográficos
Autores principales:	Wu, Dongmei, Qiu, Yifu, Gao, Xiang, Yuan, Xiao-Bing, Zhai, Qiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128079/ https://www.ncbi.nlm.nih.gov/pubmed/21738790 http://dx.doi.org/10.1371/journal.pone.0021759

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