Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA) receptor and non-structural protein 1 (NS1)...

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Detalles Bibliográficos
Autores principales: Ping, Jihui, Keleta, Liya, Forbes, Nicole E., Dankar, Samar, Stecho, William, Tyler, Shaun, Zhou, Yan, Babiuk, Lorne, Weingartl, Hana, Halpin, Rebecca A., Boyne, Alex, Bera, Jayati, Hostetler, Jessicah, Fedorova, Nadia B., Proudfoot, Katie, Katzel, Dan A., Stockwell, Tim B., Ghedin, Elodie, Spiro, David J., Brown, Earl G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128085/
https://www.ncbi.nlm.nih.gov/pubmed/21738783
http://dx.doi.org/10.1371/journal.pone.0021740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128085/
https://www.ncbi.nlm.nih.gov/pubmed/21738783
http://dx.doi.org/10.1371/journal.pone.0021740

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