Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

Mitochondria manganese superoxide dismutase (SOD2) is an important antioxidant enzyme, deficiency of which is associated with various human diseases. The known primary regulation of SOD2 is through transcriptional activation. Here, we report that SOD2 is acetylated at Lys 68 and that this acetylatio...

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Detalles Bibliográficos
Autores principales: Chen, Yaohui, Zhang, Jinye, Lin, Yan, Lei, Qunying, Guan, Kun-Liang, Zhao, Shimin, Xiong, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128277/
https://www.ncbi.nlm.nih.gov/pubmed/21566644
http://dx.doi.org/10.1038/embor.2011.65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128277/
https://www.ncbi.nlm.nih.gov/pubmed/21566644
http://dx.doi.org/10.1038/embor.2011.65

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