Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O(6)-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine

S-nitrosoglutathione reductase (GSNOR), a ubiquitously expressed protein central to the control of protein S-nitrosylation, plays critical roles in many biological systems. We showed recently that GSNOR is often deficient in human hepatocellular carcinoma and that germ line deletion of the GSNOR gen...

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Detalles Bibliográficos
Autores principales: Wei, Wei, Yang, Zhiyong, Tang, Chi-Hui, Liu, Limin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128557/
https://www.ncbi.nlm.nih.gov/pubmed/21385828
http://dx.doi.org/10.1093/carcin/bgr041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128557/
https://www.ncbi.nlm.nih.gov/pubmed/21385828
http://dx.doi.org/10.1093/carcin/bgr041

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