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Targeted deletion of GSNOR in hepatocytes of mice causes nitrosative inactivation of O(6)-alkylguanine-DNA alkyltransferase and increased sensitivity to genotoxic diethylnitrosamine
S-nitrosoglutathione reductase (GSNOR), a ubiquitously expressed protein central to the control of protein S-nitrosylation, plays critical roles in many biological systems. We showed recently that GSNOR is often deficient in human hepatocellular carcinoma and that germ line deletion of the GSNOR gen...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128557/ https://www.ncbi.nlm.nih.gov/pubmed/21385828 http://dx.doi.org/10.1093/carcin/bgr041 |