Why CCR2 and CCR5 Blockade Failed and Why CCR1 Blockade Might Still Be Effective in the Treatment of Rheumatoid Arthritis

BACKGROUND: The aim of this study was to provide more insight into the question as to why blockade of CCR1, CCR2, and CCR5 may have failed in clinical trials in rheumatoid arthritis (RA) patients, using an in vitro monocyte migration system model. METHODOLOGY/PRINCIPAL FINDINGS: Monocytes from healt...

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Detalles Bibliográficos
Autores principales: Lebre, Maria C., Vergunst, Clarissa E., Choi, Ivy Y. K., Aarrass, Saïda, Oliveira, Ana S. F., Wyant, Tim, Horuk, Richard, Reedquist, Kris A., Tak, Paul P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128605/
https://www.ncbi.nlm.nih.gov/pubmed/21747955
http://dx.doi.org/10.1371/journal.pone.0021772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128605/
https://www.ncbi.nlm.nih.gov/pubmed/21747955
http://dx.doi.org/10.1371/journal.pone.0021772

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