Loss of DNA Mismatch Repair Imparts a Selective Advantage in Planarian Adult Stem Cells

Lynch syndrome (LS) leads to an increased risk of early-onset colorectal and other types of cancer and is caused by germline mutations in DNA mismatch repair (MMR) genes. Loss of MMR function results in a mutator phenotype that likely underlies its role in tumorigenesis. However, loss of MMR also re...

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Detalles Bibliográficos
Autores principales: Hollenbach, Jessica P., Resch, Alissa M., Palakodeti, Dasaradhi, Graveley, Brenton R., Heinen, Christopher D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128615/
https://www.ncbi.nlm.nih.gov/pubmed/21747960
http://dx.doi.org/10.1371/journal.pone.0021808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128615/
https://www.ncbi.nlm.nih.gov/pubmed/21747960
http://dx.doi.org/10.1371/journal.pone.0021808

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