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Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse
BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutation is related to poor prognosis in normal-karyotype acute myeloid leukemia (AML). However, the prognostic significance of the mutation at relapse has not been adequately investigated. We investigated the prognostic s...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128906/ https://www.ncbi.nlm.nih.gov/pubmed/21747880 http://dx.doi.org/10.5045/kjh.2011.46.2.88 |
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author | Park, Sang Hyuk Chi, Hyun-Sook Min, Sook-Kyung Cho, Young-Uk Jang, Seongsoo Park, Chan-Jeoung Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Im, Ho-Joon Seo, Jong-Jin |
author_facet | Park, Sang Hyuk Chi, Hyun-Sook Min, Sook-Kyung Cho, Young-Uk Jang, Seongsoo Park, Chan-Jeoung Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Im, Ho-Joon Seo, Jong-Jin |
author_sort | Park, Sang Hyuk |
collection | PubMed |
description | BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutation is related to poor prognosis in normal-karyotype acute myeloid leukemia (AML). However, the prognostic significance of the mutation at relapse has not been adequately investigated. We investigated the prognostic significance of the FLT3 ITD mutation at relapse in normal-karyotype AML patients. METHODS: We analyzed 69 normal-karyotype AML patients, in whom paired bone marrow samples taken at initial diagnosis and subsequent relapse were analyzed for the FLT3 ITD mutation at the Asan Medical Center between 1995 and 2009. RESULTS: Forty patients showed a persistent wild-type genotype, 11 showed the FLT3 ITD mutation at diagnosis and relapse, and 9 lost and another 9 acquired the mutation at relapse. The mutation status at relapse affected the overall survival (OS), with the mutation group showing shorter OS and survival after relapse than the wild-type group did (P<0.001 and P<0.001, respectively), despite having received more frequent stem cell transplantation after relapse than the wild-type group did. However, no difference was detected in the OS and survival after relapse with regard to the mutation status at diagnosis. CONCLUSION: The patients with FLT3 ITD mutation at relapse showed poorer prognoses than those without the mutation. However, mutation status at diagnosis did not affect the outcome. These results suggest that, in normal-karyotype AML patients with relapse, the prognostic significance of FLT3 ITD mutation at relapse is greater than that of the mutation status at diagnosis. |
format | Online Article Text |
id | pubmed-3128906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis |
record_format | MEDLINE/PubMed |
spelling | pubmed-31289062011-07-11 Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse Park, Sang Hyuk Chi, Hyun-Sook Min, Sook-Kyung Cho, Young-Uk Jang, Seongsoo Park, Chan-Jeoung Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Im, Ho-Joon Seo, Jong-Jin Korean J Hematol Original Article BACKGROUND: Fms-like tyrosine kinase 3 internal tandem duplication (FLT3 ITD) mutation is related to poor prognosis in normal-karyotype acute myeloid leukemia (AML). However, the prognostic significance of the mutation at relapse has not been adequately investigated. We investigated the prognostic significance of the FLT3 ITD mutation at relapse in normal-karyotype AML patients. METHODS: We analyzed 69 normal-karyotype AML patients, in whom paired bone marrow samples taken at initial diagnosis and subsequent relapse were analyzed for the FLT3 ITD mutation at the Asan Medical Center between 1995 and 2009. RESULTS: Forty patients showed a persistent wild-type genotype, 11 showed the FLT3 ITD mutation at diagnosis and relapse, and 9 lost and another 9 acquired the mutation at relapse. The mutation status at relapse affected the overall survival (OS), with the mutation group showing shorter OS and survival after relapse than the wild-type group did (P<0.001 and P<0.001, respectively), despite having received more frequent stem cell transplantation after relapse than the wild-type group did. However, no difference was detected in the OS and survival after relapse with regard to the mutation status at diagnosis. CONCLUSION: The patients with FLT3 ITD mutation at relapse showed poorer prognoses than those without the mutation. However, mutation status at diagnosis did not affect the outcome. These results suggest that, in normal-karyotype AML patients with relapse, the prognostic significance of FLT3 ITD mutation at relapse is greater than that of the mutation status at diagnosis. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2011-06 2011-06-21 /pmc/articles/PMC3128906/ /pubmed/21747880 http://dx.doi.org/10.5045/kjh.2011.46.2.88 Text en © 2011 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Park, Sang Hyuk Chi, Hyun-Sook Min, Sook-Kyung Cho, Young-Uk Jang, Seongsoo Park, Chan-Jeoung Lee, Jung-Hee Lee, Je-Hwan Lee, Kyoo-Hyung Im, Ho-Joon Seo, Jong-Jin Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
title | Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
title_full | Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
title_fullStr | Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
title_full_unstemmed | Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
title_short | Prognostic significance of the FLT3 ITD mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
title_sort | prognostic significance of the flt3 itd mutation in patients with normal-karyotype acute myeloid leukemia in relapse |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128906/ https://www.ncbi.nlm.nih.gov/pubmed/21747880 http://dx.doi.org/10.5045/kjh.2011.46.2.88 |
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