Cargando…

Defining the geometry of the two-component proteasome degron

The eukaryotic 26S proteasome controls cellular processes by degrading specific regulatory proteins. Most proteins are targeted for degradation by a signal or degron that consists of two parts: a proteasome-binding tag, typically covalently attached polyubiquitin chains, and an unstructured region t...

Descripción completa

Detalles Bibliográficos
Autores principales: Inobe, Tomonao, Fishbain, Susan, Prakash, Sumit, Matouschek, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129032/
https://www.ncbi.nlm.nih.gov/pubmed/21278740
http://dx.doi.org/10.1038/nchembio.521