RTL551 Treatment of EAE Reduces CD226 and T-bet+ CD4 T Cells in Periphery and Prevents Infiltration of T-bet+ IL-17, IFN-γ Producing T Cells into CNS

Recombinant T cell receptor ligands (RTLs) that target encephalitogenic T-cells can reverse clinical and histological signs of EAE, and are currently in clinical trials for treatment of multiple sclerosis. To evaluate possible regulatory mechanisms, we tested effects of RTL therapy on expression of...

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Detalles Bibliográficos
Autores principales: Sinha, Sushmita, Miller, Lisa M., Subramanian, Sandhya, Burrows, Gregory G., Vandenbark, Arthur A., Offner, Halina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130056/
https://www.ncbi.nlm.nih.gov/pubmed/21750737
http://dx.doi.org/10.1371/journal.pone.0021868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130056/
https://www.ncbi.nlm.nih.gov/pubmed/21750737
http://dx.doi.org/10.1371/journal.pone.0021868

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