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Differential requirement for the dual functions of β-catenin in embryonic stem cell self-renewal and germ layer formation
Canonical Wnt-signalling has been implicated in mouse and human embryonic stem cell (ESC) maintenance, however its requirement is controversial. β-catenin is the key component in this highly conserved Wnt pathway, acting as a transcriptional transactivator. Yet, β-catenin has additional roles at the...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130149/ https://www.ncbi.nlm.nih.gov/pubmed/21685890 http://dx.doi.org/10.1038/ncb2260 |