Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA

The DNA of patients taking immunosuppressive and anti-inflammatory thiopurines contains 6-thioguanine (6-TG) and their skin is hypersensitive to ultraviolet A (UVA) radiation. DNA 6-TG absorbs UVA and generates reactive oxygen species that damage DNA and proteins. Here, we show that the DNA damage i...

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Detalles Bibliográficos
Autores principales: Gueranger, Quentin, Kia, Azadeh, Frith, David, Karran, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130278/
https://www.ncbi.nlm.nih.gov/pubmed/21398635
http://dx.doi.org/10.1093/nar/gkr112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130278/
https://www.ncbi.nlm.nih.gov/pubmed/21398635
http://dx.doi.org/10.1093/nar/gkr112

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