Cargando…

Crosslinking of DNA repair and replication proteins to DNA in cells treated with 6-thioguanine and UVA

The DNA of patients taking immunosuppressive and anti-inflammatory thiopurines contains 6-thioguanine (6-TG) and their skin is hypersensitive to ultraviolet A (UVA) radiation. DNA 6-TG absorbs UVA and generates reactive oxygen species that damage DNA and proteins. Here, we show that the DNA damage i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gueranger, Quentin, Kia, Azadeh, Frith, David, Karran, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130278/ https://www.ncbi.nlm.nih.gov/pubmed/21398635 http://dx.doi.org/10.1093/nar/gkr112

Ejemplares similares

Guanine sulphinate is a major stable product of photochemical oxidation of DNA 6-thioguanine by UVA irradiation
por: Ren, Xiaolin, et al.
Publicado: (2010)

DNA repair inhibition by UVA photoactivated fluoroquinolones and vemurafenib
por: Peacock, Matthew, et al.
Publicado: (2014)

Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions
por: Brem, Reto, et al.
Publicado: (2009)

Identification of potentially cytotoxic lesions induced by UVA photoactivation of DNA 4-thiothymidine in human cells
por: Reelfs, Olivier, et al.
Publicado: (2011)

UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages
por: Greinert, R., et al.
Publicado: (2012)

DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA
por: Mórocz, Mónika, et al.
Publicado: (2017)

FANCM interacts with PCNA to promote replication traverse of DNA interstrand crosslinks
por: Rohleder, Florian, et al.
Publicado: (2016)

Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks
por: Zhao, Junhua, et al.
Publicado: (2009)

The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair
por: Hoogenboom, Wouter S, et al.
Publicado: (2019)

RAD51 interconnects between DNA replication, DNA repair and immunity
por: Bhattacharya, Souparno, et al.
Publicado: (2017)

Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans
por: Wilson, David M., et al.
Publicado: (2017)

HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair
por: Sato, Koichi, et al.
Publicado: (2020)

A ubiquitin switch controls autocatalytic inactivation of the DNA–protein crosslink repair protease SPRTN
por: Zhao, Shubo, et al.
Publicado: (2020)

Dynamic binding of replication protein a is required for DNA repair
por: Chen, Ran, et al.
Publicado: (2016)

Proper RPA acetylation promotes accurate DNA replication and repair
por: Gan, Xiaoli, et al.
Publicado: (2023)

BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thaliana
por: Block-Schmidt, Astrid S., et al.
Publicado: (2011)

The nuclease FAN1 is involved in DNA crosslink repair in Arabidopsis thaliana independently of the nuclease MUS81
por: Herrmann, Natalie J., et al.
Publicado: (2015)

The Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair
por: Rosado, Ivan V., et al.
Publicado: (2009)

Spatial coupling between DNA replication and mismatch repair in Caulobacter crescentus
por: Chai, Tiancong, et al.
Publicado: (2021)

The structure and duplex context of DNA interstrand crosslinks affects the activity of DNA polymerase η
por: Roy, Upasana, et al.
Publicado: (2016)

Bypass of DNA interstrand crosslinks by a Rev1–DNA polymerase ζ complex
por: Bezalel-Buch, Rachel, et al.
Publicado: (2020)

SPOP promotes transcriptional expression of DNA repair and replication factors to prevent replication stress and genomic instability
por: Hjorth-Jensen, Kim, et al.
Publicado: (2018)

Zebularine induces enzymatic DNA–protein crosslinks in 45S rDNA heterochromatin of Arabidopsis nuclei
por: Prochazkova, Klara, et al.
Publicado: (2021)

Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity
por: Rodriguez-Berriguete, Gonzalo, et al.
Publicado: (2018)

DNA mismatch repair protects the genome from oxygen-induced replicative mutagenesis
por: Lózsa, Rita, et al.
Publicado: (2023)

Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks
por: Chen, Xiaorong, et al.
Publicado: (2020)

A clickable melphalan for monitoring DNA interstrand crosslink accumulation and detecting ICL repair defects in Fanconi anemia patient cells
por: Berrada, Sara, et al.
Publicado: (2023)

Structure-dependent bypass of DNA interstrand crosslinks by translesion synthesis polymerases
por: Ho, The Vinh, et al.
Publicado: (2011)

PCNA directs type 2 RNase H activity on DNA replication and repair substrates
por: Bubeck, Doryen, et al.
Publicado: (2011)

Snapshots of archaeal DNA replication and repair in living cells using super-resolution imaging
por: Delpech, Floriane, et al.
Publicado: (2018)

Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
por: Morin, José A., et al.
Publicado: (2015)

XRCC1 interacts with the p58 subunit of DNA Pol α-primase and may coordinate DNA repair and replication during S phase
por: Lévy, Nicolas, et al.
Publicado: (2009)

CSB interacts with SNM1A and promotes DNA interstrand crosslink processing
por: Iyama, Teruaki, et al.
Publicado: (2015)

Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin
por: Bauerschmidt, Christina, et al.
Publicado: (2010)

p21 promotes error-free replication-coupled DNA double-strand break repair
por: Mauro, Maurizio, et al.
Publicado: (2012)

UBR5 interacts with the replication fork and protects DNA replication from DNA polymerase η toxicity
por: Cipolla, Lina, et al.
Publicado: (2019)

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation
por: Groth, Petra, et al.
Publicado: (2012)

The interaction between cytosine methylation and processes of DNA replication and repair shape the mutational landscape of cancer genomes
por: Poulos, Rebecca C., et al.
Publicado: (2017)

Engineering of the DNA replication and repair machinery to develop binary mutators for rapid genome evolution of Corynebacterium glutamicum
por: Cai, Ningyun, et al.
Publicado: (2023)

HMGB1 interacts with XPA to facilitate the processing of DNA interstrand crosslinks in human cells
por: Mukherjee, Anirban, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_op2jtdvrp1mi2jodk37j1ld9ak