Strong negative feedback from Erk to Raf confers robustness to MAPK signalling

Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kinase in the...

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Detalles Bibliográficos
Autores principales: Fritsche-Guenther, Raphaela, Witzel, Franziska, Sieber, Anja, Herr, Ricarda, Schmidt, Nadine, Braun, Sandra, Brummer, Tilman, Sers, Christine, Blüthgen, Nils
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130559/
https://www.ncbi.nlm.nih.gov/pubmed/21613978
http://dx.doi.org/10.1038/msb.2011.27

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130559/
https://www.ncbi.nlm.nih.gov/pubmed/21613978
http://dx.doi.org/10.1038/msb.2011.27

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