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Strong negative feedback from Erk to Raf confers robustness to MAPK signalling
Protein levels within signal transduction pathways vary strongly from cell to cell. Here, we analysed how signalling pathways can still process information quantitatively despite strong heterogeneity in protein levels. We systematically perturbed the protein levels of Erk, the terminal kinase in the...
Autores principales: | Fritsche-Guenther, Raphaela, Witzel, Franziska, Sieber, Anja, Herr, Ricarda, Schmidt, Nadine, Braun, Sandra, Brummer, Tilman, Sers, Christine, Blüthgen, Nils |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Molecular Biology Organization
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130559/ https://www.ncbi.nlm.nih.gov/pubmed/21613978 http://dx.doi.org/10.1038/msb.2011.27 |
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