Lack of LDL Receptor Enhances Amyloid Deposition and Decreases Glial Response in an Alzheimer's Disease Mouse Model

BACKGROUND: Apolipoprotein E (ApoE), a cholesterol carrier associated with atherosclerosis, is a major risk factor for Alzheimer's disease (AD). The low-density lipoprotein receptor (LDLR) regulates ApoE levels in the periphery and in the central nervous system. LDLR has been identified on astr...

Descripción completa

Detalles Bibliográficos
Autores principales: Katsouri, Loukia, Georgopoulos, Spiros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130747/
https://www.ncbi.nlm.nih.gov/pubmed/21755005
http://dx.doi.org/10.1371/journal.pone.0021880

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130747/
https://www.ncbi.nlm.nih.gov/pubmed/21755005
http://dx.doi.org/10.1371/journal.pone.0021880

Ejemplares similares