Chfr and RNF8 synergistically regulate ATM activation

Protein ubiquitination is a critical component of the DNA damage response. To study the mechanism of the DNA damage-induced ubiquitination pathway, we analyzed the impact of the loss of two E3 ubiquitin ligases, RNF8 and Chfr. Interestingly, DNA damage-induced ATM activation is suppressed in RNF8 an...

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Detalles Bibliográficos
Autores principales: Wu, Jiaxue, Chen, Yibin, Lu, Lin-Yu, Wu, Yipin, Paulsen, Michelle T., Ljungman, Mats, Ferguson, David O, Yu, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130800/
https://www.ncbi.nlm.nih.gov/pubmed/21706008
http://dx.doi.org/10.1038/nsmb.2078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130800/
https://www.ncbi.nlm.nih.gov/pubmed/21706008
http://dx.doi.org/10.1038/nsmb.2078

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