Recognition of the F&H motif by the Lowe Syndrome protein OCRL

Lowe syndrome and Type 2 Dent disease are caused by defects in the inositol 5-phosphatase OCRL. Most missense mutations in the OCRL ASH-RhoGAP domain found in affected patients abolish interactions with the endocytic adaptors APPL1 and Ses (both Ses1 and Ses2), which bind OCRL through a short F&...

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Detalles Bibliográficos
Autores principales: Pirruccello, Michelle, Swan, Laura E., Folta-Stogniew, Ewa, De Camilli, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130824/
https://www.ncbi.nlm.nih.gov/pubmed/21666675
http://dx.doi.org/10.1038/nsmb.2071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130824/
https://www.ncbi.nlm.nih.gov/pubmed/21666675
http://dx.doi.org/10.1038/nsmb.2071

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