In Vivo Correction of COX Deficiency by Activation of the AMPK/PGC-1α Axis

Increased mitochondrial biogenesis by activation of PPAR- or AMPK/PGC-1α-dependent homeostatic pathways has been proposed as a treatment for mitochondrial disease. We tested this hypothesis on three recombinant mouse models characterized by defective cytochrome c-oxidase (COX) activity: a knockout (...

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Detalles Bibliográficos
Autores principales: Viscomi, Carlo, Bottani, Emanuela, Civiletto, Gabriele, Cerutti, Raffaele, Moggio, Maurizio, Fagiolari, Gigliola, Schon, Eric A., Lamperti, Costanza, Zeviani, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130927/
https://www.ncbi.nlm.nih.gov/pubmed/21723506
http://dx.doi.org/10.1016/j.cmet.2011.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130927/
https://www.ncbi.nlm.nih.gov/pubmed/21723506
http://dx.doi.org/10.1016/j.cmet.2011.04.011

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