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Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin
BACKGROUND: Recombinant human erythropoietin (rhEPO) is considered to be one of the most pivotal pharmaceutical drugs in the market because of its clinical application in the treatment of anemia-associated disorders worldwide. However, like other therapeutic proteins, it does not have suitable pharm...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131188/ https://www.ncbi.nlm.nih.gov/pubmed/21753873 http://dx.doi.org/10.2147/IJN.S19081 |