Cargando…
Translation Reinitiation Relies on the Interaction between eIF3a/TIF32 and Progressively Folded cis-Acting mRNA Elements Preceding Short uORFs
Reinitiation is a gene-specific translational control mechanism characterized by the ability of some short upstream uORFs to retain post-termination 40S subunits on mRNA. Its efficiency depends on surrounding cis-acting sequences, uORF elongation rates, various initiation factors, and the intercistr...
Autores principales: | Munzarová, Vanda, Pánek, Josef, Gunišová, Stanislava, Dányi, István, Szamecz, Béla, Valášek, Leoš Shivaya |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131280/ https://www.ncbi.nlm.nih.gov/pubmed/21750682 http://dx.doi.org/10.1371/journal.pgen.1002137 |
Ejemplares similares
-
Fail-safe mechanism of GCN4 translational control—uORF2 promotes reinitiation by analogous mechanism to uORF1 and thus secures its key role in GCN4 expression
por: Gunišová, Stanislava, et al.
Publicado: (2014) -
In vivo evidence that eIF3 stays bound to ribosomes elongating and terminating on short upstream ORFs to promote reinitiation
por: Mohammad, Mahabub Pasha, et al.
Publicado: (2017) -
eIF4G is retained on ribosomes elongating and terminating on short upstream ORFs to control reinitiation in yeast
por: Mohammad, Mahabub Pasha, et al.
Publicado: (2021) -
Small Ribosomal Protein RPS0 Stimulates Translation Initiation by Mediating 40S-Binding of eIF3 via Its Direct Contact with the eIF3a/TIF32 Subunit
por: Kouba, Tomáš, et al.
Publicado: (2012) -
In-depth analysis of cis-determinants that either promote or inhibit reinitiation on GCN4 mRNA after translation of its four short uORFs
por: Gunišová, Stanislava, et al.
Publicado: (2016)