Pathologic and Phenotypic Alterations in a Mouse Expressing a Connexin47 Missense Mutation That Causes Pelizaeus-Merzbacher–Like Disease in Humans

Gap junction channels are intercellular conduits that allow diffusional exchange of ions, second messengers, and metabolites. Human oligodendrocytes express the gap junction protein connexin47 (Cx47), which is encoded by the GJC2 gene. The autosomal recessive mutation hCx47M283T causes Pelizaeus-Mer...

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Detalles Bibliográficos
Autores principales: Tress, Oliver, Maglione, Marta, Zlomuzica, Armin, May, Dennis, Dicke, Nikolai, Degen, Joachim, Dere, Ekrem, Kettenmann, Helmut, Hartmann, Dieter, Willecke, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131295/
https://www.ncbi.nlm.nih.gov/pubmed/21750683
http://dx.doi.org/10.1371/journal.pgen.1002146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131295/
https://www.ncbi.nlm.nih.gov/pubmed/21750683
http://dx.doi.org/10.1371/journal.pgen.1002146

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