Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway

Leptin, one of the adipokines, functions as a hormone and a cytokine. In this investigation, we show for the first time that leptin, in a concentration-dependent manner, activates human peripheral blood B cells to induce secretion of IL-6, IL-10, and TNF-α. Leptin increased B cells expressing CD25 a...

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Detalles Bibliográficos
Autores principales: Agrawal, Sudhanshu, Gollapudi, Sastry, Su, Houfen, Gupta, Sudhir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132280/
https://www.ncbi.nlm.nih.gov/pubmed/21243519
http://dx.doi.org/10.1007/s10875-010-9507-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132280/
https://www.ncbi.nlm.nih.gov/pubmed/21243519
http://dx.doi.org/10.1007/s10875-010-9507-1

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