Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation

Over the last three to four decades, it has been observed that the average total hours of sleep have decreased to less than seven hours per person per night. Concomitantly, global figures relating to obesity and diabetes mellitus have increased in an alarming fashion in adults and children, and it h...

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Autores principales: AlDabal, Laila, BaHammam, Ahmed S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132857/
https://www.ncbi.nlm.nih.gov/pubmed/21754974
http://dx.doi.org/10.2174/1874306401105010031
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author AlDabal, Laila
BaHammam, Ahmed S
author_facet AlDabal, Laila
BaHammam, Ahmed S
author_sort AlDabal, Laila
collection PubMed
description Over the last three to four decades, it has been observed that the average total hours of sleep have decreased to less than seven hours per person per night. Concomitantly, global figures relating to obesity and diabetes mellitus have increased in an alarming fashion in adults and children, and it has been hypothesized that neuro-hormonal changes accompanying this behavioral sleep deprivation may lead to insulin resistance and, subsequently, to diabetes mellitus. Sleep deprivation has been associated with multiple physiological changes, including increased cortisol and ghrelin levels, decreased leptin levels and impaired glucose metabolism. Experimental studies have also shown an increase in inflammatory and pro-inflammatory markers, which are indicators of body stress, under sleep deprivation. This review elaborates further on this hypothesis, exploring the molecular basis for the link between both entities and the underlying pathophysiology that results in insulin resistance and diabetes mellitus. We review the results of experimental and epidemiological studies, specifically examining the relationship between sleep duration and the immune and endocrine systems.
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spelling pubmed-31328572011-07-13 Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation AlDabal, Laila BaHammam, Ahmed S Open Respir Med J Article Over the last three to four decades, it has been observed that the average total hours of sleep have decreased to less than seven hours per person per night. Concomitantly, global figures relating to obesity and diabetes mellitus have increased in an alarming fashion in adults and children, and it has been hypothesized that neuro-hormonal changes accompanying this behavioral sleep deprivation may lead to insulin resistance and, subsequently, to diabetes mellitus. Sleep deprivation has been associated with multiple physiological changes, including increased cortisol and ghrelin levels, decreased leptin levels and impaired glucose metabolism. Experimental studies have also shown an increase in inflammatory and pro-inflammatory markers, which are indicators of body stress, under sleep deprivation. This review elaborates further on this hypothesis, exploring the molecular basis for the link between both entities and the underlying pathophysiology that results in insulin resistance and diabetes mellitus. We review the results of experimental and epidemiological studies, specifically examining the relationship between sleep duration and the immune and endocrine systems. Bentham Open 2011-06-23 /pmc/articles/PMC3132857/ /pubmed/21754974 http://dx.doi.org/10.2174/1874306401105010031 Text en © AlDabal and BaHammam; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
AlDabal, Laila
BaHammam, Ahmed S
Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
title Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
title_full Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
title_fullStr Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
title_full_unstemmed Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
title_short Metabolic, Endocrine, and Immune Consequences of Sleep Deprivation
title_sort metabolic, endocrine, and immune consequences of sleep deprivation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132857/
https://www.ncbi.nlm.nih.gov/pubmed/21754974
http://dx.doi.org/10.2174/1874306401105010031
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