S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

Down syndrome (DS) is a developmental disorder associated with mental retardation (MR) and early onset Alzheimer's disease (AD). These CNS phenotypes are attributed to ongoing neuronal degeneration due to constitutive overexpression of chromosome 21 (HSA21) genes. We have previously shown that...

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Detalles Bibliográficos
Autores principales: Lu, Jie, Esposito, Giuseppe, Scuderi, Caterina, Steardo, Luca, Delli-Bovi, Laurent C., Hecht, Jonathan L., Dickinson, Bryan C., Chang, Christopher J., Mori, Takashi, Sheen, Volney
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133657/
https://www.ncbi.nlm.nih.gov/pubmed/21779383
http://dx.doi.org/10.1371/journal.pone.0022126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133657/
https://www.ncbi.nlm.nih.gov/pubmed/21779383
http://dx.doi.org/10.1371/journal.pone.0022126

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