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Hypoxia-Inducible Factor in Thyroid Carcinoma

Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/ra...

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Autores principales: Burrows, Natalie, Babur, Muhammad, Resch, Julia, Williams, Kaye J., Brabant, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134378/
https://www.ncbi.nlm.nih.gov/pubmed/21765994
http://dx.doi.org/10.4061/2011/762905
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author Burrows, Natalie
Babur, Muhammad
Resch, Julia
Williams, Kaye J.
Brabant, Georg
author_facet Burrows, Natalie
Babur, Muhammad
Resch, Julia
Williams, Kaye J.
Brabant, Georg
author_sort Burrows, Natalie
collection PubMed
description Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy. In addition to hypoxia, HIF-1 can be activated by growth factor-signalling pathways such as the mitogen-activated protein kinases- (MAPK-) and phosphatidylinositol-3-OH kinases- (PI3K-) signalling cascades. Mutations in these pathways are common in thyroid carcinoma and lead to enhanced HIF-1 expression and activity. Here, we summarise current data that highlights the potential role of both hypoxia and MAPK/PI3K-induced HIF-1 signalling in thyroid carcinoma progression, metastatic characteristics, and the potential role of HIF-1 in thyroid carcinoma response to radiotherapy. Direct or indirect targeting of HIF-1 using an MAPK or PI3K inhibitor in combination with radiotherapy may be a new potential therapeutic target to improve the therapeutic response of thyroid carcinoma to radiotherapy and reduce metastatic burden.
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spelling pubmed-31343782011-07-15 Hypoxia-Inducible Factor in Thyroid Carcinoma Burrows, Natalie Babur, Muhammad Resch, Julia Williams, Kaye J. Brabant, Georg J Thyroid Res Review Article Intratumoural hypoxia (low oxygen tension) is associated with aggressive disease and poor prognosis. Hypoxia-inducible factor-1 is a transcription factor activated by hypoxia that regulates the expression of genes that promote tumour cell survival, progression, metastasis, and resistance to chemo/radiotherapy. In addition to hypoxia, HIF-1 can be activated by growth factor-signalling pathways such as the mitogen-activated protein kinases- (MAPK-) and phosphatidylinositol-3-OH kinases- (PI3K-) signalling cascades. Mutations in these pathways are common in thyroid carcinoma and lead to enhanced HIF-1 expression and activity. Here, we summarise current data that highlights the potential role of both hypoxia and MAPK/PI3K-induced HIF-1 signalling in thyroid carcinoma progression, metastatic characteristics, and the potential role of HIF-1 in thyroid carcinoma response to radiotherapy. Direct or indirect targeting of HIF-1 using an MAPK or PI3K inhibitor in combination with radiotherapy may be a new potential therapeutic target to improve the therapeutic response of thyroid carcinoma to radiotherapy and reduce metastatic burden. SAGE-Hindawi Access to Research 2011-06-16 /pmc/articles/PMC3134378/ /pubmed/21765994 http://dx.doi.org/10.4061/2011/762905 Text en Copyright © 2011 Natalie Burrows et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Burrows, Natalie
Babur, Muhammad
Resch, Julia
Williams, Kaye J.
Brabant, Georg
Hypoxia-Inducible Factor in Thyroid Carcinoma
title Hypoxia-Inducible Factor in Thyroid Carcinoma
title_full Hypoxia-Inducible Factor in Thyroid Carcinoma
title_fullStr Hypoxia-Inducible Factor in Thyroid Carcinoma
title_full_unstemmed Hypoxia-Inducible Factor in Thyroid Carcinoma
title_short Hypoxia-Inducible Factor in Thyroid Carcinoma
title_sort hypoxia-inducible factor in thyroid carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134378/
https://www.ncbi.nlm.nih.gov/pubmed/21765994
http://dx.doi.org/10.4061/2011/762905
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