Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones

A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1....

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Autores principales: Bielenica, Anna, Kossakowski, Jerzy, Struga, Marta, Dybała, Izabela, Loddo, Roberta, Ibba, Cristina, La Colla, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Österreichische Apotheker-Verlagsgesellschaft 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134852/
https://www.ncbi.nlm.nih.gov/pubmed/21773062
http://dx.doi.org/10.3797/scipharm.1012-17
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author Bielenica, Anna
Kossakowski, Jerzy
Struga, Marta
Dybała, Izabela
Loddo, Roberta
Ibba, Cristina
La Colla, Paolo
author_facet Bielenica, Anna
Kossakowski, Jerzy
Struga, Marta
Dybała, Izabela
Loddo, Roberta
Ibba, Cristina
La Colla, Paolo
author_sort Bielenica, Anna
collection PubMed
description A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
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spelling pubmed-31348522011-07-19 Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones Bielenica, Anna Kossakowski, Jerzy Struga, Marta Dybała, Izabela Loddo, Roberta Ibba, Cristina La Colla, Paolo Sci Pharm Research Article A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis. Österreichische Apotheker-Verlagsgesellschaft 2011 2011-02-12 /pmc/articles/PMC3134852/ /pubmed/21773062 http://dx.doi.org/10.3797/scipharm.1012-17 Text en © Bielenica et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H., Vienna, Austria. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bielenica, Anna
Kossakowski, Jerzy
Struga, Marta
Dybała, Izabela
Loddo, Roberta
Ibba, Cristina
La Colla, Paolo
Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
title Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
title_full Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
title_fullStr Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
title_full_unstemmed Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
title_short Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
title_sort synthesis and biological evaluation of new 3-phenyl-1-[(4-arylpiperazin-1-yl)alkyl]-piperidine-2,6-diones
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134852/
https://www.ncbi.nlm.nih.gov/pubmed/21773062
http://dx.doi.org/10.3797/scipharm.1012-17
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