SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

It has become increasing clear that alterations in cellular metabolism have a key role in the generation and maintenance of cancer. Some of the metabolic changes can be attributed to the activation of oncogenes or loss of tumor suppressors. Here, we show that the mitochondrial sirtuin, SirT3, acts a...

Descripción completa

Detalles Bibliográficos
Autores principales: Bell, E L, Emerling, B M, Ricoult, S J H, Guarente, L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134877/
https://www.ncbi.nlm.nih.gov/pubmed/21358671
http://dx.doi.org/10.1038/onc.2011.37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134877/
https://www.ncbi.nlm.nih.gov/pubmed/21358671
http://dx.doi.org/10.1038/onc.2011.37

Ejemplares similares