Discovery and therapeutic potential of drugs that shift energy metabolism from mitochondrial respiration to glycolysis

Most cells can dynamically shift their relative reliance on glycolytic versus oxidative metabolism in response to nutrient availability, during development, and in disease. Studies in model systems have shown that re-directing energy metabolism from respiration to glycolysis can suppress oxidative d...

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Detalles Bibliográficos
Autores principales: Gohil, Vishal M., Sheth, Sunil A., Nilsson, Roland, Wojtovich, Andrew P., Lee, Jeong Hyun, Perocchi, Fabiana, Chen, William, Clish, Clary B., Ayata, Cenk, Brookes, Paul S., Mootha, Vamsi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135002/
https://www.ncbi.nlm.nih.gov/pubmed/20160716
http://dx.doi.org/10.1038/nbt.1606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135002/
https://www.ncbi.nlm.nih.gov/pubmed/20160716
http://dx.doi.org/10.1038/nbt.1606

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