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Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol

Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing i...

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Detalles Bibliográficos
Autores principales: Mitchell, Sarah J., Kane, Alice E., Hilmer, Sarah N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135080/
https://www.ncbi.nlm.nih.gov/pubmed/21765826
http://dx.doi.org/10.1155/2011/624156
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author Mitchell, Sarah J.
Kane, Alice E.
Hilmer, Sarah N.
author_facet Mitchell, Sarah J.
Kane, Alice E.
Hilmer, Sarah N.
author_sort Mitchell, Sarah J.
collection PubMed
description Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit.
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spelling pubmed-31350802011-07-15 Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol Mitchell, Sarah J. Kane, Alice E. Hilmer, Sarah N. Curr Gerontol Geriatr Res Review Article Optimal pharmacotherapy is determined when the pharmacokinetics and pharmacodynamics of the drug are understood. However, the age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variation mean optimal dose selection are a challenge for prescribing in older adults. Poor understanding of how hepatic clearance and toxicity are different with age results in suboptimal dose selection, poor efficacy, and/or increased toxicity. Of particular concern is the analgesic paracetamol which has been in use for more than 50 years and is consumed by a large proportion of older adults. Paracetamol is considered to be a relatively safe drug; however, caution must be taken because of its potential for toxicity. Paracetamol-induced liver injury from accidental overdose accounts for up to 55% of cases in older adults. Better understanding of how age affects the hepatic clearance and toxicity of drugs will contribute to evidence-based prescribing for older people, leading to fewer adverse drug reactions without loss of benefit. Hindawi Publishing Corporation 2011 2011-05-11 /pmc/articles/PMC3135080/ /pubmed/21765826 http://dx.doi.org/10.1155/2011/624156 Text en Copyright © 2011 Sarah J. Mitchell et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mitchell, Sarah J.
Kane, Alice E.
Hilmer, Sarah N.
Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
title Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
title_full Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
title_fullStr Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
title_full_unstemmed Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
title_short Age-Related Changes in the Hepatic Pharmacology and Toxicology of Paracetamol
title_sort age-related changes in the hepatic pharmacology and toxicology of paracetamol
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135080/
https://www.ncbi.nlm.nih.gov/pubmed/21765826
http://dx.doi.org/10.1155/2011/624156
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