Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates

Hybrid molecules combining photoactivated aryl acetylenes and a dicationic lysine moiety cause the most efficient double-strand (ds) DNA cleavage known to date for a small molecule. In order to test the connection between the alkylating ability and the DNA-damaging properties of these compounds, we...

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Detalles Bibliográficos
Autores principales: Yang, Wang-Yong, Marrone, Samantha A, Minors, Nalisha, Zorio, Diego A R, Alabugin, Igor V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2011
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135214/
https://www.ncbi.nlm.nih.gov/pubmed/21804877
http://dx.doi.org/10.3762/bjoc.7.93

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135214/
https://www.ncbi.nlm.nih.gov/pubmed/21804877
http://dx.doi.org/10.3762/bjoc.7.93

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