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Ionic mechanisms and Ca(2+) dynamics underlying the glucose response of pancreatic β cells: a simulation study
To clarify the mechanisms underlying the pancreatic β-cell response to varying glucose concentrations ([G]), electrophysiological findings were integrated into a mathematical cell model. The Ca(2+) dynamics of the endoplasmic reticulum (ER) were also improved. The model was validated by demonstratin...
Autores principales: | Cha, Chae Young, Nakamura, Yasuhiko, Himeno, Yukiko, Wang, JianWu, Fujimoto, Shinpei, Inagaki, Nobuya, Earm, Yung E, Noma, Akinori |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135323/ https://www.ncbi.nlm.nih.gov/pubmed/21708953 http://dx.doi.org/10.1085/jgp.201110611 |
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