Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice

Production of the cytokines IL-4 and IL-13 is increased in both human asthma and mouse asthma models, and Stat6 activation by the common IL-4/IL-13R drives most mouse model pathophysiology, including airway hyperresponsiveness (AHR). However, the precise cellular mechanisms through which IL-4Rα indu...

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Detalles Bibliográficos
Autores principales: Perkins, Charles, Yanase, Noriko, Smulian, George, Gildea, Lucy, Orekov, Tatyana, Potter, Crystal, Brombacher, Frank, Aronow, Bruce, Wills-Karp, Marsha, Finkelman, Fred D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135339/
https://www.ncbi.nlm.nih.gov/pubmed/21464224
http://dx.doi.org/10.1084/jem.20100023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135339/
https://www.ncbi.nlm.nih.gov/pubmed/21464224
http://dx.doi.org/10.1084/jem.20100023

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