Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

Toll-like receptor (TLR) 9 requires proteolytic processing in the endolysosome to initiate signaling in response to DNA. However, recent studies conflict as to which proteases are required for receptor cleavage. We show that TLR9 proteolysis is a multistep process. The first step removes the majorit...

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Detalles Bibliográficos
Autores principales: Ewald, Sarah E., Engel, Alex, Lee, Jiyoun, Wang, Miqi, Bogyo, Matthew, Barton, Gregory M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135342/
https://www.ncbi.nlm.nih.gov/pubmed/21402738
http://dx.doi.org/10.1084/jem.20100682

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135342/
https://www.ncbi.nlm.nih.gov/pubmed/21402738
http://dx.doi.org/10.1084/jem.20100682

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