Destruction of tumor vasculature and abated tumor growth upon VEGF blockade is driven by proapoptotic protein Bim in endothelial cells

For malignant growth, solid cancers must stimulate the formation of new blood vessels by producing vascular endothelial growth factor (VEGF-A), which is required for the survival of tumor-associated vessels. Novel anticancer agents that block VEGF-A signaling trigger endothelial cell (EC) apoptosis...

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Detalles Bibliográficos
Autores principales: Naik, Edwina, O'Reilly, Lorraine A., Asselin-Labat, Marie-Liesse, Merino, Delphine, Lin, Ann, Cook, Michele, Coultas, Leigh, Bouillet, Philippe, Adams, Jerry M., Strasser, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135358/
https://www.ncbi.nlm.nih.gov/pubmed/21646395
http://dx.doi.org/10.1084/jem.20100951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135358/
https://www.ncbi.nlm.nih.gov/pubmed/21646395
http://dx.doi.org/10.1084/jem.20100951

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