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A biosensor generated via high throughput screening quantifies cell edge Src dynamics
Fluorescent biosensors for living cells currently require laborious optimization and a unique design for each target. They are limited by the availability of naturally occurring ligands with appropriate target specificity. Here we describe a biosensor based on an engineered fibronectin monobody scaf...
Autores principales: | Gulyani, Akash, Vitriol, Eric, Allen, Richard, Wu, Jianrong, Gremyachinskiy, Dmitriy, Lewis, Steven, Dewar, Brian, Graves, Lee M., Kay, Brian K., Kuhlman, Brian, Elston, Tim, Hahn, Klaus M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135387/ https://www.ncbi.nlm.nih.gov/pubmed/21666688 http://dx.doi.org/10.1038/nchembio.585 |
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