Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Mammals lacking BLOC-3 have impaired formation of melanosomes, a type of lysosome-related organelle (LRO), and, in earlier work, we found that a subunit of the BLOC-3 complex inhibits loading of Argonaute (Ago) proteins with small ribonucleic acids (RNAs) in Drosophila melanogaster cells. Small RNAs...

Descripción completa

Detalles Bibliográficos
Autores principales: Harris, Dinari A., Kim, Kevin, Nakahara, Kenji, Vásquez-Doorman, Constanza, Carthew, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135410/
https://www.ncbi.nlm.nih.gov/pubmed/21746852
http://dx.doi.org/10.1083/jcb.201102021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135410/
https://www.ncbi.nlm.nih.gov/pubmed/21746852
http://dx.doi.org/10.1083/jcb.201102021

Ejemplares similares