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Cargo sorting to lysosome-related organelles regulates siRNA-mediated gene silencing

Mammals lacking BLOC-3 have impaired formation of melanosomes, a type of lysosome-related organelle (LRO), and, in earlier work, we found that a subunit of the BLOC-3 complex inhibits loading of Argonaute (Ago) proteins with small ribonucleic acids (RNAs) in Drosophila melanogaster cells. Small RNAs...

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Detalles Bibliográficos
Autores principales:	Harris, Dinari A., Kim, Kevin, Nakahara, Kenji, Vásquez-Doorman, Constanza, Carthew, Richard W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135410/ https://www.ncbi.nlm.nih.gov/pubmed/21746852 http://dx.doi.org/10.1083/jcb.201102021

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