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Different metastasis promotive potency of small G-proteins RalA and RalB in in vivo hamster tumor model
BACKGROUND: Previously we have shown that oncogenic Ha-Ras stimulated in vivo metastasis through RalGEF-Ral signaling. RalA and RalB are highly homologous small G proteins belonging to Ras superfamily. They can be activated by Ras-RalGEF signaling pathway and influence cellular growth and survival,...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135494/ https://www.ncbi.nlm.nih.gov/pubmed/21714887 http://dx.doi.org/10.1186/1475-2867-11-22 |