17-DMAG diminishes hemorrhage-induced small intestine injury by elevating Bcl-2 protein and inhibiting iNOS pathway, TNF-α increase, and caspase-3 activation

BACKGROUND: Hemorrhage increases inducible nitric oxide synthase (iNOS) and depletes ATP levels in various tissues. Previous studies have shown that geldanamycin, an inducer of heat shock protein 70kDa (HSP-70) and inhibitor of iNOS, limits both processes. Reduction in NO production limits lipid per...

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Detalles Bibliográficos
Autores principales: Kiang, Juliann G, Agravante, Neil G, Smith, Joan T, Bowman, Phillip D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135504/
https://www.ncbi.nlm.nih.gov/pubmed/21711488
http://dx.doi.org/10.1186/2045-3701-1-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135504/
https://www.ncbi.nlm.nih.gov/pubmed/21711488
http://dx.doi.org/10.1186/2045-3701-1-21

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