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A Novel Role of Protein Tyrosine Kinase2 in Mediating Chloride Secretion in Human Airway Epithelial Cells

Ca(2+) activated Cl(−) channels (CaCC) are up-regulated in cystic fibrosis (CF) airway surface epithelia. The presence and functional properties of CaCC make it a possible therapeutic target to compensate for the deficiency of Cl(−) secretion in CF epithelia. CaCC is activated by an increase in cyto...

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Detalles Bibliográficos
Autores principales: Liang, Lihua, Woodward, Owen M., Chen, Zhaohui, Cotter, Robert, Guggino, William B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135607/
https://www.ncbi.nlm.nih.gov/pubmed/21765932
http://dx.doi.org/10.1371/journal.pone.0021991