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Gene Expression Pattern in Transmitochondrial Cytoplasmic Hybrid Cells Harboring Type 2 Diabetes-Associated Mitochondrial DNA Haplogroups

Decreased mitochondrial function plays a pivotal role in the pathogenesis of type 2 diabetes mellitus (T2DM). Recently, it was reported that mitochondrial DNA (mtDNA) haplogroups confer genetic susceptibility to T2DM in Koreans and Japanese. Particularly, mtDNA haplogroup N9a is associated with a de...

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Detalles Bibliográficos
Autores principales: Hwang, Seungwoo, Kwak, Soo Heon, Bhak, Jong, Kang, Hae Sun, Lee, You Ri, Koo, Bo Kyung, Park, Kyong Soo, Lee, Hong Kyu, Cho, Young Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135611/
https://www.ncbi.nlm.nih.gov/pubmed/21765942
http://dx.doi.org/10.1371/journal.pone.0022116