Network Neighbors of Drug Targets Contribute to Drug Side-Effect Similarity

In pharmacology, it is essential to identify the molecular mechanisms of drug action in order to understand adverse side effects. These adverse side effects have been used to infer whether two drugs share a target protein. However, side-effect similarity of drugs could also be caused by their target...

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Detalles Bibliográficos
Autores principales: Brouwers, Lucas, Iskar, Murat, Zeller, Georg, van Noort, Vera, Bork, Peer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135612/
https://www.ncbi.nlm.nih.gov/pubmed/21765950
http://dx.doi.org/10.1371/journal.pone.0022187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135612/
https://www.ncbi.nlm.nih.gov/pubmed/21765950
http://dx.doi.org/10.1371/journal.pone.0022187

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