Intra-Accumbens Injection of a Dopamine Aptamer Abates MK-801-Induced Cognitive Dysfunction in a Model of Schizophrenia

Systemic administration of the noncompetitive NMDA-receptor antagonist, MK-801, has been proposed to model cognitive deficits similar to those seen in patients with schizophrenia. The present work investigated the ability of a dopamine-binding DNA aptamer to regulate these MK-801-induced cognitive d...

Descripción completa

Detalles Bibliográficos
Autores principales: Holahan, Matthew R., Madularu, Dan, McConnell, Erin M., Walsh, Ryan, DeRosa, Maria C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135623/
https://www.ncbi.nlm.nih.gov/pubmed/21779401
http://dx.doi.org/10.1371/journal.pone.0022239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135623/
https://www.ncbi.nlm.nih.gov/pubmed/21779401
http://dx.doi.org/10.1371/journal.pone.0022239

Ejemplares similares