Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds

Conjugation of siRNA to macromolecules such as serum albumin has multiple potential benefits, including enhanced extravasation via albumin-mediated transcytosis across endothelial cells and reduced renal clearance. In attempting to conjugate siRNA to albumin, we used commercially sourced amine-modif...

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Detalles Bibliográficos
Autores principales: Lau, Shannen, Graham, Bim, Boyd, Ben J., Pouton, Colin W., White, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136096/
https://www.ncbi.nlm.nih.gov/pubmed/21772990
http://dx.doi.org/10.4061/2011/154609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136096/
https://www.ncbi.nlm.nih.gov/pubmed/21772990
http://dx.doi.org/10.4061/2011/154609

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