Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand

The indolocarbazole derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) has demonstrated a high potency (at nanomolar to submicromolar concentrations) towards the NCI panel of human tumor cell lines and transplanted tumors. Intercalation into the DNA double helix...

Descripción completa

Detalles Bibliográficos
Autores principales: Kaluzhny, Dmitry N., Shchyolkina, Anna K., Ilyinsky, Nikolay S., Borisova, Olga F., Shtil, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136114/
https://www.ncbi.nlm.nih.gov/pubmed/21772991
http://dx.doi.org/10.4061/2011/184735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136114/
https://www.ncbi.nlm.nih.gov/pubmed/21772991
http://dx.doi.org/10.4061/2011/184735

Ejemplares similares