Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity

The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks. The primary mode of interaction between BRCA2 and RAD51 is through the BRC rep...

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Detalles Bibliográficos
Autores principales: Cole, Daniel J., Rajendra, Eeson, Roberts-Thomson, Meredith, Hardwick, Bryn, McKenzie, Grahame J., Payne, Mike C., Venkitaraman, Ashok R., Skylaris, Chris-Kriton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136434/
https://www.ncbi.nlm.nih.gov/pubmed/21789034
http://dx.doi.org/10.1371/journal.pcbi.1002096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136434/
https://www.ncbi.nlm.nih.gov/pubmed/21789034
http://dx.doi.org/10.1371/journal.pcbi.1002096

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