Cargando…

Interrogation of the Protein-Protein Interactions between Human BRCA2 BRC Repeats and RAD51 Reveals Atomistic Determinants of Affinity

The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks. The primary mode of interaction between BRCA2 and RAD51 is through the BRC rep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cole, Daniel J., Rajendra, Eeson, Roberts-Thomson, Meredith, Hardwick, Bryn, McKenzie, Grahame J., Payne, Mike C., Venkitaraman, Ashok R., Skylaris, Chris-Kriton
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136434/ https://www.ncbi.nlm.nih.gov/pubmed/21789034 http://dx.doi.org/10.1371/journal.pcbi.1002096

Ejemplares similares

Two modules in the BRC repeats of BRCA2 mediate structural and functional interactions with the RAD51 recombinase
por: Rajendra, Eeson, et al.
Publicado: (2010)

The Carboxyl Terminus of Brca2 Links the Disassembly of Rad51 Complexes to Mitotic Entry
por: Ayoub, Nabieh, et al.
Publicado: (2009)

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange
por: Shivji, Mahmud K. K., et al.
Publicado: (2006)

BRCA2 BRC missense variants disrupt RAD51-dependent DNA repair
por: Jimenez-Sainz, Judit, et al.
Publicado: (2022)

Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity
por: Chatterjee, Gouri, et al.
Publicado: (2016)

A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats
por: Zhu, Zida, et al.
Publicado: (2023)

A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
por: Scott, Duncan E., et al.
Publicado: (2021)

Divergent binding mode for a protozoan BRC repeat to RAD51
por: Pantelejevs, Teodors, et al.
Publicado: (2022)

Design of Potent Inhibitors of Human RAD51 Recombinase Based on BRC Motifs of BRCA2 Protein: Modeling and Experimental Validation of a Chimera Peptide
por: Nomme, Julian, et al.
Publicado: (2010)

A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor
por: Lee, M, et al.
Publicado: (2011)

Trypanosoma brucei BRCA2 acts in a life cycle-specific genome stability process and dictates BRC repeat number-dependent RAD51 subnuclear dynamics
por: Trenaman, Anna, et al.
Publicado: (2013)

Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction
por: Subramanyam, Shyamal, et al.
Publicado: (2013)

Atomistic simulations on the carbidisation processes in Pd nanoparticles
por: Kordatos, Apostolos, et al.
Publicado: (2023)

Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases
por: Scott, Duncan E, et al.
Publicado: (2015)

Atomistic level characterisation of ssDNA translocation through the E. coli proteins CsgG and CsgF for nanopore sequencing
por: Rattu, Punam, et al.
Publicado: (2021)

Regulation and pharmacological targeting of RAD51 in cancer
por: Grundy, McKenzie K, et al.
Publicado: (2020)

Homologous Pairing Activities of Two Rice RAD51 Proteins, RAD51A1 and RAD51A2
por: Morozumi, Yuichi, et al.
Publicado: (2013)

Structure‐activity relationship of the peptide binding‐motif mediating the BRCA2:RAD51 protein–protein interaction
por: Scott, Duncan E., et al.
Publicado: (2016)

Effects of the Missense Mutations in Canine BRCA2 on BRC Repeat 3 Functions and Comparative Analyses between Canine and Human BRC Repeat 3
por: Yoshikawa, Yasunaga, et al.
Publicado: (2012)

Corrigendum to “Atomistic level characterisation of ssDNA translocation through the E. coli proteins CsgG and CsgF for nanopore sequencing” [Comput. Struct. Biotechnol. J. 19 (2021) 6417–6430]
por: Rattu, Punam, et al.
Publicado: (2022)

Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations
por: Gonzalez, R, et al.
Publicado: (1999)

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered ssDNA
por: Liu, Jie, et al.
Publicado: (2010)

Engineering Archeal Surrogate Systems for the Development of Protein–Protein Interaction Inhibitors against Human RAD51
por: Moschetti, Tommaso, et al.
Publicado: (2016)

Non-Recombinogenic Functions of Rad51, BRCA2, and Rad52 in DNA Damage Tolerance
por: Prado, Félix
Publicado: (2021)

Overcoming Chemical, Biological, and Computational Challenges in the Development of Inhibitors Targeting Protein-Protein Interactions
por: Laraia, Luca, et al.
Publicado: (2015)

Purified human BRCA2 stimulates RAD51-mediated recombination
por: Jensen, Ryan B., et al.
Publicado: (2010)

Genetic instability in the RAD51 and BRCA1 regions in breast cancer
por: Nowacka-Zawisza, Maria, et al.
Publicado: (2006)

Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
por: Appleby, Robert, et al.
Publicado: (2023)

Arabidopsis RAD51, RAD51C and XRCC3 proteins form a complex and facilitate RAD51 localization on chromosomes for meiotic recombination
por: Su, Hang, et al.
Publicado: (2017)

BRC criteria revised.
Publicado: (1996)

Polarized Protein-Specific Charges from Atoms-in-Molecule Electron Density Partitioning
por: Lee, Louis P., et al.
Publicado: (2013)

Computational Analysis of Phosphopeptide Binding to the Polo-Box Domain of the Mitotic Kinase PLK1 Using Molecular Dynamics Simulation
por: Huggins, David J., et al.
Publicado: (2010)

Clinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2, and RAD51C Status
por: Cunningham, J. M., et al.
Publicado: (2014)

Surfactant Proteins A and D: Trimerized Innate Immunity Proteins with an Affinity for Viral Fusion Proteins
por: Watson, Alastair, et al.
Publicado: (2018)

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament
por: Ma, Chu Jian, et al.
Publicado: (2017)

BRCA2 Acts as RAD51 Loader to Facilitate Telomere Replication and Capping
por: Badie, Sophie, et al.
Publicado: (2010)

Conformational flexibility and oligomerization of BRCA2 regions induced by RAD51 interaction
por: Sidhu, Arshdeep, et al.
Publicado: (2020)

Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes
por: Deveryshetty, Jaigeeth, et al.
Publicado: (2023)

RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51
por: Kovalenko, Oleg V., et al.
Publicado: (2006)

Roles of XRCC2, RAD51B and RAD51D in RAD51-Independent SSA Recombination
por: Serra, Heïdi, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_50lsftlb6ula3baceks7r6r2f6