Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies

The Plasmodium falciparum lactate dehydrogenase enzyme (PfLDH) has been considered as a potential molecular target for antimalarials due to this parasite's dependence on glycolysis for energy production. Because the LDH enzymes found in P. vivax, P. malariae and P. ovale (pLDH) all exhibit ∼90%...

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Detalles Bibliográficos
Autores principales: Penna-Coutinho, Julia, Cortopassi, Wilian Augusto, Oliveira, Aline Alves, França, Tanos Celmar Costa, Krettli, Antoniana Ursine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136448/
https://www.ncbi.nlm.nih.gov/pubmed/21779323
http://dx.doi.org/10.1371/journal.pone.0021237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136448/
https://www.ncbi.nlm.nih.gov/pubmed/21779323
http://dx.doi.org/10.1371/journal.pone.0021237

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