Mutant Prourokinase with Adjunctive C1-Inhibitor Is an Effective and Safer Alternative to tPA in Rat Stroke

A single-site mutant (M5) of native urokinase plasminogen activator (prouPA) induces effective thrombolysis in dogs with venous or arterial thrombosis with a reduction in bleeding complications compared to tPA. This effect, related to inhibition of two-chain M5 (tcM5) by plasma C1-inhibitor (C1I), t...

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Detalles Bibliográficos
Autores principales: Tomasi, Simone, Sarmientos, Paolo, Giorda, Giada, Gurewich, Victor, Vercelli, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136496/
https://www.ncbi.nlm.nih.gov/pubmed/21779364
http://dx.doi.org/10.1371/journal.pone.0021999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136496/
https://www.ncbi.nlm.nih.gov/pubmed/21779364
http://dx.doi.org/10.1371/journal.pone.0021999

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